Molecular Origins of Life, Munich 2023

Sitzung

Session II

20.06.2023, 12:00

Online

Vorsitzende der Sitzung

Session II: Talks

• Hannes Mutschler (TU Dortmund, DE)
• Philippe Nghe (ESPCI-PSL, France)

Session II: Q&A

• In diesem Block gibt es keine Vorsitzenden

59. Towards a protein-free biology

Hannes Mutschler (TU Dortmund, DE)

20.06.23, 12:00

Polynucleic acids such as RNA are thought to have played a central role in the origin of life on Earth. Similar to modern biology, replication and rearrangement of sequence information were most likely essential for the evolutionary development of simple life forms. However, neither the catalysts, cofactors, nor environmental conditions that were necessary for these reactions are known. Using...

60. Assessing the probability of autocatalytic RNAs using generative models and high-throughput screening

Philippe Nghe (ESPCI-PSL, France)

20.06.23, 12:25

The RNA world hypothesis proposes that RNAs carry catalytic activity necessary for primordial evolution. A first necessary condition for evolution is reproduction. Whether self-reproduction is rare or common in the space of RNA sequences is central to assess the plausibility of this scenario. To date, two ribozymes have been shown to autocatalytically sustain their self-reproduction in the...