Prebiotic synthesis of complex organic molecules in water-rich environments remains a challenge. However, recent observations of liquid CO₂ in the deep sea suggest the presence of benthic CO₂ pools, prompting a new hypothesis that a liquid/supercritical CO₂ (ScCO₂)-water two-phase system could enable condensation reactions by mimicking dry conditions. To test this, we conducted nucleoside...
Takumi Okuda, Claudia Höbartner*
A variety of RNA modifications, collectively known as epitranscriptome, have been discovered across all classes of RNA, with over 150 distinct types identified in modern organisms. Among these modifications, methylation is the most abundant and simplest modification, carried out by enzymes using the ubiquitous methyl donor S-adenosylmethionine (SAM). In...
