Speaker
Toshiko Ichiye
(Georgetown U, US)
Description
Our interest is in the evolution and adaptation of enzymes at a structural level to extreme environments. Understanding how temperature and pressure can affect where organism can survive may also provide a history of early life looked like. We are particularly interested if evolution towards or way extremes influences outcomes. Now, we are using Alpha Fold, a machine learning method, to expand the number of structures and molecular dynamics simulations to determine “material science” measures to quantitate P-T diagrams of how proteins vary with pressure and temperature.