Aug 25 – 27, 2021
Online
Europe/Berlin timezone

Emergent by-products of evolution

Aug 27, 2021, 3:00 PM
25m
Online

Online

Due to unstable situation with Covid-19 the event will be held online!

Speaker

Irene Chen (UCLA)

Description

The earliest living systems may have used RNA to both carry genetic information and catalyze chemical reactions. The sequence-activity relationship of RNA can be captured by a ‘fitness landscape’, or the mapping of activity over all possible sequence space. Fitness landscapes describe the emergence of functional RNA by delineating possible evolutionary pathways as well as capturing the absolute frequency of functional sequences. We have developed a method to map fitness landscapes for catalytic RNA, revealing the fundamental structure of the evolutionary landscape. We also study how RNA fitness is affected by encapsulation inside an experimental model of simple cells (membrane vesicle ‘protocells’). Biophysical effects of encapsulation on the RNA can lead to emergent properties influencing RNA evolution in this system.

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