Molecular Origins of Life, Munich 2022

Sitzung

Session D

16.06.2022, 15:30

(talks will be broadcasted) (Literaturhaus München)

54. Towards RNA-life from 2’,3’-cyclic nucleotides at CO2-water interfaces

Dieter Braun (LMU Munich, DE)

16.06.22, 15:30

A way to study the emergence of life is to create a physico-chemical system that is capable of open ended evolution. The aim is to search for most minimal requirements to maximize the probability to find it outside the lab. Starting life with three molecules in a one-pot geological non-equilibrium without human intervention would be a favorable scenario.
We revisited polymerization and...

68. A catalytic RNA that generates GTP

Ulrich Müller (UCSD, US)

16.06.22, 15:55

Synthesis of RNA in early life forms required chemically activated nucleotides, perhaps in the same form of nucleoside 5′-triphosphates (NTPs) as in the contemporary biosphere. Here we show the development of a catalytic RNA (ribozyme) that generates the nucleoside triphosphate guanosine 5′-triphosphate (GTP) from the nucleoside guanosine and the prebiotically plausible cyclic trimetaphosphate...

62. Evolution and Adaptation of Enzymes to Extreme Environments

Toshiko Ichiye (Georgetown U, US)

16.06.22, 16:20

Our interest is in the evolution and adaptation of enzymes at a structural level to extreme environments. Understanding how temperature and pressure can affect where organism can survive may also provide a history of early life looked like. We are particularly interested if evolution towards or way extremes influences outcomes. Now, we are using Alpha Fold, a machine learning method, to...